Canos
A sample tube in a laboratory rack, black and white photograph

THE SCIENCE

Signals within plasma cell-free DNA.

Cells shed fragments of DNA into the bloodstream. Their sequence, their physical characteristics and their epigenetic marks carry information about the tissue they came from.

A breakthrough already transforming human cancer care.

In human oncology, liquid biopsies analyse cell-free DNA in blood for molecular patterns associated with cancer.

Canos brings that scientific approach into veterinary medicine, combining genomic, physical and epigenetic information from canine cell-free DNA.

SPECIMEN · 5 ML · CELL-FREE DNA PRESERVATION TUBE

It starts with 5 mL of blood.

A routine blood draw collected by a veterinarian into a specialised preservation tube.

cfDNA BCT · 5 mLCANINE PLASMASPECIMENCN-0000

SCROLL

cfDNA BCT · 5 mLCANINE PLASMASPECIMENCN-0000

INSIDE THE SAMPLE

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Separate

Plasma

The tube is spun. The plasma fraction is taken forward; the cellular fraction is not.

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Cancer doesn’t leave one signal. It changes many.

Canos reads multiple properties of cell-free DNA together, including epigenetic patterns, fragment characteristics and genome-wide changes, to build a richer molecular picture.

CANOS — INTEGRATED MOLECULAR FIELDA · FRAGMENT LENGTH DISTRIBUTION100167250334420BASE PAIRSTHIS SAMPLE — MODE SHIFTED SHORTERREFERENCE POPULATIONB · EPIGENETIC SIGNAL ACROSS CPG BLOCKSGENOMIC POSITION →HYPERMETHYLATED BLOCKSC · GENOME-WIDE CHANGE · CANINE AUTOSOMES 1–3815913172125293337GAINLOSSD · CELL-FREE DNA CONCENTRATIONTHIS SAMPLEREFERENCE DISTRIBUTION · NG/MLE · TISSUE SIGNAL INFERRED FROM THE PATTERNS ABOVEHAEMATOPOIETICHEPATICEPITHELIALOTHER / UNRESOLVEDNOT A MEASURED INPUT — DERIVED FROM MOLECULAR PATTERN
A dog in the field, black and white photograph

Human-level cancer science. For dogs.

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